Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates

BACKGROUND: Classical major histocompatibility complex (MHC) class II molecules play an essential role in presenting peptide antigens to CD4(+) T lymphocytes in the acquired immune system. The non-classical class II DM molecule, HLA-DM in the case of humans, possesses critical function in assisting...

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Publicado en:BMC Evol Biol
Autores principales: Dijkstra, Johannes M, Grimholt, Unni, Leong, Jong, Koop, Ben F, Hashimoto, Keiichiro
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219347/
https://ncbi.nlm.nih.gov/pubmed/24279922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-13-260
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