Parkin regulates kainate receptors by interacting with the GluK2 subunit

Although loss-of-function mutations in the PARK2 gene, the gene that encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, the responsible molecular mechanisms remain unclear. Evidence suggests that a loss of parkin dysregulates excitatory synapses. Here we show that parkin in...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Maraschi, AnnaMaria, Ciammola, Andrea, Folci, Alessandra, Sassone, Francesca, Ronzitti, Giuseppe, Cappelletti, Graziella, Silani, Vincenzo, Sato, Shigeto, Hattori, Nobutaka, Mazzanti, Michele, Chieregatti, Evelina, Mulle, Christophe, Passafaro, Maria, Sassone, Jenny
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218952/
https://ncbi.nlm.nih.gov/pubmed/25316086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6182
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