The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes

Dysregulated Toll-Like Receptor (TLR) signalling and genetic polymorphisms in these proteins are linked to many human diseases. We investigated TLR4 functional variants D299G and T399I to assess the impact on LPS-induced responsiveness in comparison to wild-type TLR4. The mechanism by which this occ...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hold, Georgina L., Berry, Susan, Saunders, Karin A., Drew, Janice, Mayer, Claus, Brookes, Heather, Gay, Nick J., El-Omar, Emad M., Bryant, Clare E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218727/
https://ncbi.nlm.nih.gov/pubmed/25365308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111460
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