A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses

Two cosegregating single-nucleotide polymorphisms (SNPs) in human TLR4, an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4986791 (T399I), have been associated with LPS hyporesponsiveness and differential susceptibility to many infectious or inflammatory diseases. However...

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Udgivet i:J Exp Med
Main Authors: Richard, Katharina, Piepenbrink, Kurt H., Shirey, Kari Ann, Gopalakrishnan, Archana, Nallar, Shreeram, Prantner, Daniel J., Perkins, Darren J., Lai, Wendy, Vlk, Alexandra, Toshchakov, Vladimir Y., Feng, Chiguang, Fanaroff, Rachel, Medvedev, Andrei E., Blanco, Jorge C.G., Vogel, Stefanie N.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685774/
https://ncbi.nlm.nih.gov/pubmed/33216117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200675
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