A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses

Two cosegregating single-nucleotide polymorphisms (SNPs) in human TLR4, an A896G transition at SNP rs4986790 (D299G) and a C1196T transition at SNP rs4986791 (T399I), have been associated with LPS hyporesponsiveness and differential susceptibility to many infectious or inflammatory diseases. However...

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Gepubliceerd in:J Exp Med
Hoofdauteurs: Richard, Katharina, Piepenbrink, Kurt H., Shirey, Kari Ann, Gopalakrishnan, Archana, Nallar, Shreeram, Prantner, Daniel J., Perkins, Darren J., Lai, Wendy, Vlk, Alexandra, Toshchakov, Vladimir Y., Feng, Chiguang, Fanaroff, Rachel, Medvedev, Andrei E., Blanco, Jorge C.G., Vogel, Stefanie N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685774/
https://ncbi.nlm.nih.gov/pubmed/33216117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200675
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