SC-09 TARGETING GLIOBLASTOMA STEM CELLS VIA INHIBITION OF PI3K/AKT PATHWAY ALONE AND IN COMBINATION WITH AUTOPHAGY BLOCKADE

BACKGROUND: Glioblastoma Multiforme (GBM) is the most aggressive form of malignant primary brain tumor. A subset of glioblastoma cells, known as glioblastoma stem-like cells (GSCs), are chemotherapy and radiotherapy-resistent and are hypothesized to be responsible for tumor formation, maintenance, a...

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Publié dans:Neuro Oncol
Auteurs principaux: Graham, Regina, Benito, Daniel, Soni, Neil, Uddin, Raisa, Zhang, Baoyu, Walters, Winston, Bregy, Amade, Komotar, Ricardo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218604/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou275.9
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