IT-22 TARGETING THE IMMUNE CHECKPOINT NETWORK WITH miR-138 EXERTS THERAPEUTIC EFFICACY IN MURINE MODELS OF GLIOMA

Antibody therapeutic targeting of the immune checkpoints CTLA-4 and PD-1 has demonstrated marked tumor regression in clinical trials; however, this requires multimodality treatment and has known toxicity. MicroRNAs (miRNAs) can modulate gene transcripts, including those of tumor-mediated immune supp...

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Huvudupphovsmän: Nduom, Edjah K., Wei, Jun, Kong, Ling-Yuan, Xu, Shuo, Gabrusiewicz, Konrad, Ling, Xiaoyang, Huang, Neal, Qiao, Wei, Zhou, Shouhao, Ivan, Cristina, Chen, Jie Qing, Ji, Yongjie, Radvanyi, Laszlo, Fuller, Greg N., Gilbert, Mark, Conrad, Charles A., Overwijk, Willem, Calin, George A., Heimberger, Amy B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
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Abstracts
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218239/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou258.20
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