IB-09 STING AGONIST INDUCES POTENT ANTI-GLIOMA IMMUNITY VIA INDUCTION OF TYPE-I IFN SIGNALS IN THE TUMOR MICROENVIRONMENT

While type-I interferons (IFNs) play critical roles in antiviral and antitumor activity, it remains to be elucidated how type-I IFNs are produced in sterile conditions of the tumor microenvironment and directly impacts tumor-infiltrating immune cells. We report that both human and de novo mouse glio...

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Main Authors: Ohkuri, Takayuki, Ghosh, Arundhati, Kosaka, Akemi, Zhu, Jianzhong, Ikeura, Maki, David, Michael, Watkins, Simon, Sarkar, Saumendra, Okada, Hideho
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218226/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou257.9
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