IB-03 IDH MUTANT GLIOMAS ARE RESISTANT TO NATURAL KILLER CELL-MEDIATED CYTOLYSIS

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are common in gliomas. 50-80% of WHO II/III gliomas possess IDH1/IDH2 mutation. Methylation-related transcriptional repression is a feature of IDH mutant (IDHmut) tumors. Epigenetic repression of natural killer (NK) cell ligands is a comm...

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Autores principales: Brancho, Michael, Chang, Yigang, Zhang, Xioran, Okada, Hideho, Li, Aofei, Grandi, Paola, Lotze, Michael, Amankulor, Nduka
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218220/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou257.3
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