ET-62 HIGHLY SELECTIVE ACTIVITY OF MDM2 INHIBITOR RG7112 AGAINST MDM2-AMPLIFIED/TP53 WILD-TYPE GLIOBLASTOMAS

Alteration of P53 pathway is one of the key molecular events involved in glioblastoma (GBM) biology. Genetic alterations which reduce TP53 function in GBM include MDM2 amplification (14% of patients), MDM4 amplification (7%), and TP53 gene mutations (35%), each of which is generally thought to be mu...

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Autori principali: Verreault, Maite, Levasseur, Camille, Schmitt, Charlotte, Guehennec, Jeremy, Labussiere, Marianne, Marie, Yannick, Haidar, Sam, Mokhtari, Karima, Hoang-Xuan, Khe, Sanson, Marc, Ligon, Keith, Delattre, Jean-Yves, Idbaih, Ahmed
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218158/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.59
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