ET-39 REPEATED PHARMACOLOGICAL DOSES OF ASCORBATE PROTECTS TUMOURS FROM RADIATION DAMAGE IN AN INTRACRANIAL MOUSE GLIOMA MODEL

High dose ascorbate is used as an anti-cancer treatment by complementary and alternative medicine. In the acidic, metal-rich tumour environment ascorbate acts as a pro-oxidant, generating free radicals and DNA damage, similar to ionising radiation. We showed that addition of high-dose ascorbate to r...

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Main Authors: McConnell, Melanie, Grasso, Carole, Fabre, Marie-Sophie, Collis, Sarah, Castro, Leticia, Schleich, Nanette, Herst, Patries
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218136/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.39
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