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High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

We have previously shown that exposure to high dose ascorbate causes double stranded breaks (DSBs) and a build-up in S-phase in glioblastoma (GBM) cell lines. Here we investigated whether or not this was due to genotoxic stress as well as metabolic stress generated by exposure to high dose ascorbate...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Castro, Maria Leticia, Carson, Georgia M., McConnell, Melanie J., Herst, Patries M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618086/
https://ncbi.nlm.nih.gov/pubmed/28737676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox6030058
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