EG-07 CELL CYCLE SIGNATURE AND TUMOR PHYLOGENY ARE ENCODED IN THE EVOLUTIONARY DYNAMICS OF DNA METHYLATION IN GLIOMA

The clonal evolution of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast, tumor epigenetic states, including DNA methylation, are reversible and sensitive to the tumor microenvironment, presumably precluding the use of epigenetics to discover tumor phylog...

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Main Authors: Mazor, Tali, Pankov, Aleksandr, Johnson, Brett E., Hong, Chibo, Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael, Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Song, Jun S., Berger, Mitchel S., Chang, Susan M., Costello, Joseph F.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218101/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou254.7
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