GENE-35. MGMT PROMOTER METHYLATION IN NEWLY DIAGNOSED LGG AS A POTENTIAL BIOMARKER FOR TMZ-ASSOCIATED HYPERMUTATION AT RECURRENCE

Low-grade gliomas (LGGs), which include grade II astrocytoma and grade II oligodendroglioma, inevitably recur despite aggressive treatment with surgery, and sometimes, with radiation and the chemotherapeutic agent temozolomide (TMZ). The clinical benefit of TMZ in LGG is unclear, and a subset of TMZ...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Mathur, Radhika, Zhang, Yalan, Grimmer, Matthew, Hong, Chibo, Berger, Mitchel, Molinaro, Annette, Ann Oberheim-Bush, Nancy, Chang, Susan, Costello, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genetics and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847238/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.437
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