PATH-12. TEMOZOLOMIDE-INDUCED HYPERMUTATION IS ASSOCIATED WITH HIGH-GRADE TRANSFORMATION, DISTANT RECURRENCE AND REDUCED SURVIVAL IN INITIALLY LOW GRADE IDH-MUTANT GLIOMAS

Temozolomide, a commonly used alkylating agent, can induce somatic hypermutation in gliomas. The prevalence and implications of this phenomenon are not well characterized. Using targeted and whole exome sequencing from a cohort of 82 patients with recurrent IDH-mut LGG, we evaluated the clinical imp...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Yu, Yao, Villanueva-Meyer, Javier, Chang, Susan, Grimmer, Matthew, Hilz, Stephanie, Solomon, David, Choi, Serah, Wahl, Michael, Mazor, Tali, Hong, Chibo, Shai, Anny, Phillips, Joanna, McDermott, Michael, Haas-Kogan, Daphne, Taylor, Jennie, Butowski, Nicholas, Clarke, Jennifer, Berger, Mitchel, Costello, Joseph, Bush, Nancy Ann Oberheim
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Molecular Pathology & Classification
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651214/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.694
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