DR-02 TEMOZOLOMIDE SENSITIZES GLIOMA STEM CELLS TO TRAIL-INDUCED APOPTOSIS THROUGH UPREGULATION OF c-CBL

TRAIL-induced apoptosis is inhibited in GSCs. In this study, we investgated whether or not the widely used chemotherapeutic agent-TMZ can sensitize TRAIL treatment in GSCs, related mechanism was investigated in cultured glioma stem cells (GSCs) and primary glioma cells (PGCs) from patients. We found...

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Hauptverfasser: Jing, Zhitao, Li, Long, Liu, Jia, Wang, Minghao, Ban, Yunchao, Wu, Anhua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218041/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou252.2
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