DN-03 MUTANT IDH1-DRIVEN CELLULAR TRANSFORMATION INCREASES RAD51-MEDIATED HOMOLOGOUS RECOMBINATION AND TEMOZOLOMIDE RESISTANCE

Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower-grade glioma, and not only drive gliomagenesis but are associated with longer patient survival and improved response to temozolomide (TMZ). To investigate the possible causative relationship between these events, we introduced wild-type...

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Autori principali: Ohba, Shigeo, Mukherjee, Joydeep, See, Wendy, Pieper, Russell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218030/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou245.3
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