CB-18 INTERROGATION OF SUB-CLONAL GENETIC DIVERSITY OF HUMAN GBM REVEALS GENETIC HETEROGENEITY IN TUMOUR-PROPAGATING CELLS, WHICH DISPLAY VARIABLE COMPETITIVE CAPACITY FOR TUMOUR PROPAGATION IN VIVO

BACKGROUND: Glioblastoma (GB) is a lethal malignancy whose clinical intransigence has been linked to extensive intra-clonal genetic and phenotypic diversity and the common emergence of therapeutic resistance. This interpretation embodies an implicit assumption that cancer stem cells or tumour propag...

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Hauptverfasser: Watts, Colin, Piccirillo, Sara, Kearney, Lyndal, Potter, Nicola, van Delft, Frederik, Coleman, Sue, Lillis, Suzanne, Carnicer, Maria-Jose, Greaves, Mel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217954/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou241.17
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