BI-22 CORRELATION OF MOLECULAR SUBTYPES WITH OVERALL SURVIVAL (OS) IN AVAGLIO, A RANDOMIZED, PLACEBO-CONTROLLED STUDY OF BEVACIZUMAB (BEV) PLUS RADIOTHERAPY (RT) AND TEMOZOLOMIDE (TMZ) FOR NEWLY DIAGNOSED GLIOBLASTOMA (GBM)

BACKGROUND: Factors that correlate the extent of clinical benefit with anti-VEGF therapy are poorly understood. Two phase 3 trials in newly diagnosed GBM (AVAglio and RTOG-0825) reported that BEV + RT/TMZ prolonged progression-free survival but not OS, versus placebo + RT/TMZ. Specific GBM patient s...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Phillips, Heidi, Sandmann, Thomas, Li, Congfen, Cloughesy, Timothy, Chinot, Olivier L., Wick, Wolfgang, Nishikawa, Ryo, Mason, Warren, Henriksson, Roger, Saran, Frank, Lai, Albert, Moore, Nicola, Hegde, Priti, Abrey, Lauren, Bourgon, Richard, Garcia, Josep, Bais, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217890/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou239.22
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