A Phosphate-Binding Pocket Within the Platform-PAZ-Connector Helix Cassette of Human Dicer

We have solved two families of crystal structures of human Dicer ‘platform-PAZ-connector helix’ cassette in complex with siRNAs. The structures possess two adjacently positioned pockets: a 2-nucleotide 3′-overhang-binding pocket within the PAZ domain (3′-pocket) and a newly identified phosphate-bind...

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Bibliografiske detaljer
Main Authors: Tian, Yuan, Simanshu, Dhirendra K., Ma, Jin-Biao, Park, Jong-Eun, Heo, Inha, Kim, V. Narry, Patel, Dinshaw J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217634/
https://ncbi.nlm.nih.gov/pubmed/24486018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.003
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