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Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
In Drosophila, Dicer-1 produces microRNAs (miRNAs) from pre-miRNAs, whereas Dicer-2 generates small interfering RNAs from long double-stranded RNA (dsRNA), a process that requires ATP hydrolysis. We previously showed that inorganic phosphate inhibits Dicer-2 cleavage of pre-miRNAs, but not long dsRN...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989643/ https://ncbi.nlm.nih.gov/pubmed/24488111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201387176 |
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