Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes

Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with man...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pratt, Ashley J., Shin, David S., Merz, Gregory E., Rambo, Robert P., Lancaster, W. Andrew, Dyer, Kevin N., Borbat, Peter P., Poole, Farris L., Adams, Michael W. W., Freed, Jack H., Crane, Brian R., Tainer, John A., Getzoff, Elizabeth D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217430/
https://ncbi.nlm.nih.gov/pubmed/25316790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308531111
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