Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes

Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with man...

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Dades bibliogràfiques
Autors principals: Pratt, Ashley J., Shin, David S., Merz, Gregory E., Rambo, Robert P., Lancaster, W. Andrew, Dyer, Kevin N., Borbat, Peter P., Poole, Farris L., Adams, Michael W. W., Freed, Jack H., Crane, Brian R., Tainer, John A., Getzoff, Elizabeth D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217430/
https://ncbi.nlm.nih.gov/pubmed/25316790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308531111
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