Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

The receptor-interacting kinase-3 (RIP3) and its downstream substrate mixed lineage kinase domain-like protein (MLKL) have emerged as the key cellular components in programmed necrotic cell death. Receptors for the cytokines of tumor necrosis factor (TNF) family and Toll-like receptors (TLR) 3 and 4...

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Hlavní autoři: Wang, Xing, Li, Yun, Liu, Shan, Yu, Xiaoliang, Li, Lin, Shi, Cuilin, He, Wenhui, Li, Jun, Xu, Lei, Hu, Zhilin, Yu, Lu, Yang, Zhongxu, Chen, Qin, Ge, Lin, Zhang, Zili, Zhou, Biqi, Jiang, Xuejun, Chen, She, He, Sudan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217423/
https://ncbi.nlm.nih.gov/pubmed/25316792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412767111
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