Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

Receptor-interacting protein kinase 3 (RIP3) and its substrate mixed-lineage kinase domain-like protein (MLKL) are core regulators of programmed necrosis. The elimination of pathogen-infected cells by programmed necrosis acts as an important host defense mechanism. Here, we report that human herpes...

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Udgivet i:J Virol
Main Authors: Yu, Xiaoliang, Li, Yun, Chen, Qin, Su, Chenhe, Zhang, Zili, Yang, Chengkui, Hu, Zhilin, Hou, Jue, Zhou, Jinying, Gong, Ling, Jiang, Xuejun, Zheng, Chunfu, He, Sudan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702709/
https://ncbi.nlm.nih.gov/pubmed/26559832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02446-15
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