Computational design of a red fluorophore ligase for site-specific protein labeling in living cells

Chemical fluorophores offer tremendous size and photophysical advantages over fluorescent proteins but are much more challenging to target to specific cellular proteins. Here, we used Rosetta-based computation to design a fluorophore ligase that accepts the red dye resorufin, starting from Escherich...

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Bibliografiske detaljer
Main Authors: Liu, Daniel S., Nivón, Lucas G., Richter, Florian, Goldman, Peter J., Deerinck, Thomas J., Yao, Jennifer Z., Richardson, Douglas, Phipps, William S., Ye, Anne Z., Ellisman, Mark H., Drennan, Catherine L., Baker, David, Ting, Alice Y.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217414/
https://ncbi.nlm.nih.gov/pubmed/25313043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404736111
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