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Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition
Reengineering protein–protein recognition is an important route to dissecting and controlling complex interaction networks. Experimental approaches have used the strategy of “second-site suppressors,” where a functional interaction is inferred between two proteins if a mutation in one protein can be...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217408/ https://ncbi.nlm.nih.gov/pubmed/25313039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410624111 |
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