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Intestinal myofibroblast-specific Tpl2-Cox-2-PGE(2) pathway links innate sensing to epithelial homeostasis
Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell types recently found to be genetically associated with inflammatory bowel diseases (IBDs). Here we show that Tpl2 may exert a dominant homeostatic rather than inflammatory function in the intestine mediated speci...
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| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217397/ https://ncbi.nlm.nih.gov/pubmed/25316791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415762111 |
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