Intestinal myofibroblast-specific Tpl2-Cox-2-PGE(2) pathway links innate sensing to epithelial homeostasis

Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell types recently found to be genetically associated with inflammatory bowel diseases (IBDs). Here we show that Tpl2 may exert a dominant homeostatic rather than inflammatory function in the intestine mediated speci...

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Detalhes bibliográficos
Main Authors: Roulis, Manolis, Nikolaou, Christoforos, Kotsaki, Elena, Kaffe, Eleanna, Karagianni, Niki, Koliaraki, Vasiliki, Salpea, Klelia, Ragoussis, Jiannis, Aidinis, Vassilis, Martini, Eva, Becker, Christoph, Herschman, Harvey R., Vetrano, Stefania, Danese, Silvio, Kollias, George
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217397/
https://ncbi.nlm.nih.gov/pubmed/25316791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415762111
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