Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer

PURPOSE: In a recent Phase II clinical trial, low dose (100 mg/kg) gemcitabine showed promise as a radiosensitiser in bladder cancer but underlying mechanisms lack elucidation. Here we investigated the mechanism of radiosensitisation by low-dose gemcitabine in bladder cancer cell lines. EXPERIMENTAL...

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Hauptverfasser: Kerr, Martin, Scott, Helen E, Groselj, Blaz, Stratford, Michael RL, Karaszi, Katalin, Sharma, Naomi L, Kiltie, Anne E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216732/
https://ncbi.nlm.nih.gov/pubmed/25224279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0542
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