CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

OBJECTIVE: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcription factor CREB. Here, we test CREB function in th...

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Detalhes bibliográficos
Main Authors: Shin, Soona, Le Lay, John, Everett, Logan J., Gupta, Rana, Rafiq, Kiran, Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216406/
https://ncbi.nlm.nih.gov/pubmed/25379405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.08.001
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