Pyroglutamylated Amyloid-β Peptide Reverses Cross β-Sheets by a Prion-Like Mechanism

[Image: see text] The amyloid hypothesis causatively relates the fibrillar deposits of amyloid β peptide (Aβ) to Alzheimer’s disease (AD). More recent data, however, identify the soluble oligomers as the major cytotoxic entities. Pyroglutamylated Aβ (pE-Aβ) is present in AD brains and exerts augment...

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Main Authors: Matos, Jason O., Goldblatt, Greg, Jeon, Jaekyun, Chen, Bo, Tatulian, Suren A.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216196/
https://ncbi.nlm.nih.gov/pubmed/24802697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp412743s
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