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Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides
Amyloid β peptide (Aβ) is causatively associated with Alzheimer’s disease (AD), and N-terminally truncated and pyroglutamylated Aβ peptides (AβpE) exert hypertoxic effect by an unknown mechanism. Recent evidence has identified the prefibrillar oligomers of Aβ, not the fibrils, as the prevalent cytot...
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| 出版年: | Phys Chem Chem Phys |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4668202/ https://ncbi.nlm.nih.gov/pubmed/26214017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cp03343h |
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