Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2ʹ-deoxycytidine-triggered invasiveness

5-Aza-2ʹ-deoxycytidine (5-azaCdR) not only inhibits growth of non-invasive breast cancer cells but also increases their invasiveness through induction of pro-metastatic genes. Methylated DNA binding protein 2 (MBD2) is involved in silencing methylated tumor suppressor genes as well as activation of...

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Detalhes bibliográficos
Main Authors: Cheishvili, David, Chik, Flora, Li, Chen Chen, Bhattacharya, Bishnu, Suderman, Matthew, Arakelian, Ani, Hallett, Michael, Rabbani, Shafaat A., Szyf, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216057/
https://ncbi.nlm.nih.gov/pubmed/25178277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu181
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