Whole Exome Sequencing Identifies Novel Genes for Fetal Hemoglobin Response to Hydroxyurea in Children with Sickle Cell Anemia

Hydroxyurea has proven efficacy in children and adults with sickle cell anemia (SCA), but with considerable inter-individual variability in the amount of fetal hemoglobin (HbF) produced. Sibling and twin studies indicate that some of that drug response variation is heritable. To test the hypothesis...

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Detalhes bibliográficos
Main Authors: Sheehan, Vivien A., Crosby, Jacy R., Sabo, Aniko, Mortier, Nicole A., Howard, Thad A., Muzny, Donna M., Dugan-Perez, Shannon, Aygun, Banu, Nottage, Kerri A., Boerwinkle, Eric, Gibbs, Richard A., Ware, Russell E., Flanagan, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215999/
https://ncbi.nlm.nih.gov/pubmed/25360671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110740
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