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ATP Allosterically Activates the Human 5-Lipoxygenase Molecular Mechanism of Arachidonic Acid and 5(S)-Hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid
[Image: see text] 5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A(4), from a single polyunsaturated fatty acid. This work investigates the ki...
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| Main Authors: | , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American
Chemical Society
2014
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4215895/ https://ncbi.nlm.nih.gov/pubmed/24893149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401621d |
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