ATP Allosterically Activates the Human 5-Lipoxygenase Molecular Mechanism of Arachidonic Acid and 5(S)-Hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid

[Image: see text] 5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A(4), from a single polyunsaturated fatty acid. This work investigates the ki...

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Bibliographic Details
Main Authors: Smyrniotis, Christopher J., Barbour, Shannon R., Xia, Zexin, Hixon, Mark S., Holman, Theodore R.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215895/
https://ncbi.nlm.nih.gov/pubmed/24893149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401621d
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