Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three d...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Siegel, M I, McConnell, R T, Cuatrecasas, P
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1979
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383916/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/115007/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.8.3774
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