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Application of Screening Experimental Designs to Assess Chromatographic Isotope Effect upon Isotope-Coded Derivatization for Quantitative Liquid Chromatography–Mass Spectrometry
[Image: see text] Isotope effect may cause partial chromatographic separation of labeled (heavy) and unlabeled (light) isotopologue pairs. Together with a simultaneous matrix effect, this could lead to unacceptable accuracy in quantitative liquid chromatography–mass spectrometry assays, especially w...
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| Main Authors: | , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American
Chemical
Society
2014
|
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4215859/ https://ncbi.nlm.nih.gov/pubmed/24922593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac501309s |
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