Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

Nearly 8% of the human population carries an inactivating point mutation in the gene that encodes the cardioprotective enzyme aldehyde dehydrogenase 2 (ALDH2). This genetic polymorphism (ALDH2*2) is linked to more severe outcomes from ischemic heart damage and an increased risk of coronary artery di...

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Hauptverfasser: Ebert, Antje D., Kodo, Kazuki, Liang, Ping, Wu, Haodi, Huber, Bruno C., Riegler, Johannes, Churko, Jared, Lee, Jaecheol, de Almeida, Patricia, Lan, Feng, Diecke, Sebastian, Burridge, Paul W., Gold, Joseph D., Mochly-Rosen, Daria, Wu, Joseph C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215699/
https://ncbi.nlm.nih.gov/pubmed/25253673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009027
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