Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

Nearly 8% of the human population carries an inactivating point mutation in the gene that encodes the cardioprotective enzyme aldehyde dehydrogenase 2 (ALDH2). This genetic polymorphism (ALDH2*2) is linked to more severe outcomes from ischemic heart damage and an increased risk of coronary artery di...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ebert, Antje D., Kodo, Kazuki, Liang, Ping, Wu, Haodi, Huber, Bruno C., Riegler, Johannes, Churko, Jared, Lee, Jaecheol, de Almeida, Patricia, Lan, Feng, Diecke, Sebastian, Burridge, Paul W., Gold, Joseph D., Mochly-Rosen, Daria, Wu, Joseph C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215699/
https://ncbi.nlm.nih.gov/pubmed/25253673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009027
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky