Cerebellar pathology in Friedreich's ataxia: Atrophied dentate nuclei with normal iron content

BACKGROUND: In Friedreich's ataxia (FA) the genetically decreased expression of the mitochondrial protein frataxin leads to disturbance of the mitochondrial iron metabolism. Within the cerebellum the dentate nuclei (DN) are primarily affected. Histopathological studies show atrophy and accumula...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Solbach, K., Kraff, O., Minnerop, M., Beck, A., Schöls, L., Gizewski, E.R., Ladd, M.E., Timmann, D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215469/
https://ncbi.nlm.nih.gov/pubmed/25379420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2014.08.018
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