Mouse Macrophages Completely Lacking Rho Subfamily GTPases (RhoA, RhoB, and RhoC) Have Severe Lamellipodial Retraction Defects, but Robust Chemotactic Navigation and Altered Motility

RhoA is thought to be essential for coordination of the membrane protrusions and retractions required for immune cell motility and directed migration. Whether the subfamily of Rho (Ras homolog) GTPases (RhoA, RhoB, and RhoC) is actually required for the directed migration of primary cells is difficu...

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Detalhes bibliográficos
Principais autores: Königs, Volker, Jennings, Richard, Vogl, Thomas, Horsthemke, Markus, Bachg, Anne C., Xu, Yan, Grobe, Kay, Brakebusch, Cord, Schwab, Albrecht, Bähler, Martin, Knaus, Ulla G., Hanley, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215254/
https://ncbi.nlm.nih.gov/pubmed/25213860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563270
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