Nuclear Factor-κB-inducing Kinase (NIK) Contains an Amino-terminal Inhibitor of Apoptosis (IAP)-binding Motif (IBM) That Potentiates NIK Degradation by Cellular IAP1 (c-IAP1)

Activation of the noncanonical NF-κB pathway hinges on the stability of the NF-κB-inducing kinase (NIK), which is kept at low levels basally by a protein complex consisting of the E3 ubiquitin ligases cellular inhibitor of apoptosis 1 and 2 (c-IAP1/2) proteins and the tumor necrosis factor receptor-...

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Detalhes bibliográficos
Main Authors: Lee, Sunhee, Challa-Malladi, Madhavi, Bratton, Shawn B., Wright, Casey W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215246/
https://ncbi.nlm.nih.gov/pubmed/25246529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587808
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