Biocompatible Anionic Polymeric Microspheres as Priming Delivery System for Effetive HIV/AIDS Tat-Based Vaccines

Here we describe a prime-boost regimen of vaccination in Macaca fascicularis that combines priming with novel anionic microspheres designed to deliver the biologically active HIV-1 Tat protein and boosting with Tat in Alum. This regimen of immunization modulated the IgG subclass profile and elicited...

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Autores principales: Titti, Fausto, Maggiorella, Maria T., Ferrantelli, Flavia, Sernicola, Leonardo, Bellino, Stefania, Collacchi, Barbara, Belasio, Emanuele Fanales, Moretti, Sonia, Pavone Cossut, Maria Rosaria, Belli, Roberto, Olivieri, Erika, Farcomeni, Stefania, Compagnoni, Daniela, Michelini, Zuleika, Sabbatucci, Michela, Sparnacci, Katia, Tondelli, Luisa, Laus, Michele, Cafaro, Aurelio, Caputo, Antonella, Ensoli, Barbara
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214729/
https://ncbi.nlm.nih.gov/pubmed/25356594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111360
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