HIV-1 Tat Promotes Integrin-Mediated HIV Transmission to Dendritic Cells by Binding Env Spikes and Competes Neutralization by Anti-HIV Antibodies

Use of Env in HIV vaccine development has been disappointing. Here we show that, in the presence of a biologically active Tat subunit vaccine, a trimeric Env protein prevents in monkeys virus spread from the portal of entry to regional lymph nodes. This appears to be due to specific interactions bet...

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Main Authors: Monini, Paolo, Cafaro, Aurelio, Srivastava, Indresh K., Moretti, Sonia, Sharma, Victoria A., Andreini, Claudia, Chiozzini, Chiara, Ferrantelli, Flavia, Cossut, Maria R. Pavone., Tripiciano, Antonella, Nappi, Filomena, Longo, Olimpia, Bellino, Stefania, Picconi, Orietta, Fanales-Belasio, Emanuele, Borsetti, Alessandra, Toschi, Elena, Schiavoni, Ilaria, Bacigalupo, Ilaria, Kan, Elaine, Sernicola, Leonardo, Maggiorella, Maria T., Montin, Katy, Porcu, Marco, Leone, Patrizia, Leone, Pasqualina, Collacchi, Barbara, Palladino, Clelia, Ridolfi, Barbara, Falchi, Mario, Macchia, Iole, Ulmer, Jeffrey B., Buttò, Stefano, Sgadari, Cecilia, Magnani, Mauro, Federico, Maurizio P. M., Titti, Fausto, Banci, Lucia, Dallocchio, Franco, Rappuoli, Rino, Ensoli, Fabrizio, Barnett, Susan W., Garaci, Enrico, Ensoli, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496724/
https://ncbi.nlm.nih.gov/pubmed/23152803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048781
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