Biocompatible Anionic Polymeric Microspheres as Priming Delivery System for Effetive HIV/AIDS Tat-Based Vaccines

Here we describe a prime-boost regimen of vaccination in Macaca fascicularis that combines priming with novel anionic microspheres designed to deliver the biologically active HIV-1 Tat protein and boosting with Tat in Alum. This regimen of immunization modulated the IgG subclass profile and elicited...

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Detalhes bibliográficos
Main Authors: Titti, Fausto, Maggiorella, Maria T., Ferrantelli, Flavia, Sernicola, Leonardo, Bellino, Stefania, Collacchi, Barbara, Belasio, Emanuele Fanales, Moretti, Sonia, Pavone Cossut, Maria Rosaria, Belli, Roberto, Olivieri, Erika, Farcomeni, Stefania, Compagnoni, Daniela, Michelini, Zuleika, Sabbatucci, Michela, Sparnacci, Katia, Tondelli, Luisa, Laus, Michele, Cafaro, Aurelio, Caputo, Antonella, Ensoli, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214729/
https://ncbi.nlm.nih.gov/pubmed/25356594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111360
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