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Liver-specific Knockout of GRP94 in Mice Disrupts Cell Adhesion, Activates Liver Progenitor Cells, and Accelerates Liver Tumorigenesis
Liver cancer is one of the most common solid tumors with poor prognosis and high mortality. Mutation or deletion of the tumor suppressor PTEN is strongly correlated with human liver cancer. Glucose-regulated protein 94 (GRP94) is a major endoplasmic reticulum (ER) chaperone protein, but its in vivo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4214272/ https://ncbi.nlm.nih.gov/pubmed/24027047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26711 |
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