Lapatinib Antagonizes Multidrug Resistance–Associated Protein 1–Mediated Multidrug Resistance by Inhibiting Its Transport Function

Lapatinib, a tyrosine kinase inhibitor, is used in the treatment of advanced or metastatic breast cancer overexpressing human epidermal receptor 2 (HER2). Lapatinib can modulate the function of ATP-binding cassette (ABC) transporters (ABCB1 and ABCG2), which are the major mechanism responsible for m...

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Detalhes bibliográficos
Main Authors: Ma, Shao-lin, Hu, Ya-peng, Wang, Fang, Huang, Zhen-cong, Chen, Yi-fan, Wang, Xiao-kun, Fu, Li-wu
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212010/
https://ncbi.nlm.nih.gov/pubmed/25105301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00059
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