Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

BACKGROUND: ABCC1 and ABCG2 are ubiquitous ATP-binding cassette transmembrane proteins that play an important role in multidrug resistance (MDR). In this study, we evaluated the possible interaction of vandetanib, an orally administered drug inhibiting multiple receptor tyrosine kinases, with ABCC1...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zheng, Li-sheng, Wang, Fang, Li, Yu-hong, Zhang, Xu, Chen, Li-ming, Liang, Yong-ju, Dai, Chun-ling, Yan, Yan-yan, Tao, Li-yang, Mi, Yan-jun, Yang, An-kui, To, Kenneth Kin Wah, Fu, Li-wu
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2009
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669214/
https://ncbi.nlm.nih.gov/pubmed/19390592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005172
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