Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

BACKGROUND: ABCC1 and ABCG2 are ubiquitous ATP-binding cassette transmembrane proteins that play an important role in multidrug resistance (MDR). In this study, we evaluated the possible interaction of vandetanib, an orally administered drug inhibiting multiple receptor tyrosine kinases, with ABCC1...

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Detalhes bibliográficos
Main Authors: Zheng, Li-sheng, Wang, Fang, Li, Yu-hong, Zhang, Xu, Chen, Li-ming, Liang, Yong-ju, Dai, Chun-ling, Yan, Yan-yan, Tao, Li-yang, Mi, Yan-jun, Yang, An-kui, To, Kenneth Kin Wah, Fu, Li-wu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669214/
https://ncbi.nlm.nih.gov/pubmed/19390592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005172
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