ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein

P-glycoprotein (P-gp) pumps multiple types of drugs out of the cell, using energy generated from ATP, and confers multidrug resistance (MDR) on cancer cells. ZD6474 is an orally active, selective inhibitor of the vascular endothelial growth factor receptor, epidermal growth factor receptor, and rear...

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Bibliographic Details
Main Authors: Mi, Y, Lou, L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360411/
https://ncbi.nlm.nih.gov/pubmed/17912240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603985
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