Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein

Development of multidrug resistance (MDR) is a continuous clinical challenge partially due to the overexpression of P-glycoprotein (P-gp) for chronic myelogenous leukemia (CML) patients. Herein, we evaluated the inhibitory potency of emodin, a natural anthraquinone derivative isolated from Rheum pal...

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Опубликовано в: :PLoS One
Главные авторы: Min, Hongping, Niu, Miaomiao, Zhang, Weilin, Yan, Jia, Li, Jiachang, Tan, Xiying, Li, Bo, Su, Mengxiang, Di, Bin, Yan, Fang
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679605/
https://ncbi.nlm.nih.gov/pubmed/29121121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187971
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