Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood–brain barrier

Methotrexate (MTX) is the single most effective agent for the treatment of primary central nervous system lymphoma. Currently, the delivery of MTX to the brain is achieved by high systemic doses, which cause severe long-term neurotoxicity, or intrathecal administration, which is highly invasive and...

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Hlavní autoři: Wang, Xiang, Liu, Ping, Yang, Weixiao, Li, Lu, Li, Peijing, Liu, Zheng, Zhuo, Zhongxiong, Gao, Yunhua
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211917/
https://ncbi.nlm.nih.gov/pubmed/25364248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S69845
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